Depo-Medrol can weaken your immune system, making it easier for you to get an infection. Steroids can also worsen an infection you already have, or reactivate an infection you recently had. Tell your doctor about any illness or infection you have had within the past several weeks. So the immune system works overtime around the clock trying to get rid of this nasty foreign substance. Adrenal glands think it’s emergency time all the time, so they pump out the hormone cortisol. Pretty soon, the adrenals are completely exhausted. Summary. Immune system disorder is found among people who take Depo-provera, especially for people who are female, 10-19 old , have been taking the drug for 1 - 6 months, also take medication Amoxicillin, and have Infection. Immune system and depo provera All the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice. Since zinc is one of the most important nutrients for proper functioning of the immune system, oral contraceptive-induced depletion of zinc may weaken the immune system in susceptible women. Oral contraceptives also deplete magnesium. Can the depo shot compromise your immune system? I have now heard so many horror stories about it and have been on it for a little over a year I believe. I recently moved to Utah and work outside everyday. Depo-Provera (medroxyprogesterone acetate) is a form of progesterone, a female hormone used as contraception to prevent pregnancy. Depo-Provera is also used to reduce pain cause by endometriosis, and to ease pain and symptoms in women with metastatic uterine or kidney cancer. They act to trigger your immune system to make the right cells to destroy that type of virus. The immune system is tricked into doing it, it doesn't do it because you are actually sick. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Harris on immune system and depo provera: Hello Shalonda, Depo provera does not take 12 months to get out of your system or it would be a once a year shot and not an every 3 months shot. If you stop taking depo provera (medroxyprogesterone) it will be out of your. Depo-Provera Sterile Aqueous Suspension contains medroxyprogesterone acetate, which is a derivative of progesterone and is active by the parenteral and oral routes of administration.